Stay healthy with a glass of wine a day

Washington: Moderate alcohol consumption can boost your immune system and potentially improve your ability to fight infections, a new study has claimed.
 

A research team led by an immunologist at the University of California, Riverside found that moderate consumption of alcohol can improve immune response to vaccination.
 

The finding could pave the way for potentially new interventions to improve our ability to respond to vaccines and infections, benefiting vulnerable populations, such as the elderly for whom the flu vaccine, for example, has been found to be largely ineffective.
 

"It has been known for a long time that moderate alcohol consumption is associated with lower mortality," said Ilhem Messaoudi, an associate professor of biomedical sciences in the School of Medicine and lead author of the study published in the journal Vaccine.
 

"Our study, conducted on non-human  primates, shows for the first time that voluntary moderate alcohol consumption boosts immune responses to vaccination," Messaoudi said.
 

To study the impact of alcohol consumption on the immune system, the researchers trained 12 rhesus macaques to self-administer/consume alcohol on their own accord. The team first vaccinated the animals (against small pox) and then allowed them to access either 4 per cent ethanol (the experimental group) or calorically matched sugar water (the control group).
 

All the animals also had open access to water as an alternative fluid, as well as food. The researchers monitored the animals' daily ethanol consumption for 14 months. The animals were vaccinated one more time, seven months after the experiment began.
 

The research team found that over nine months of the animals' ethanol self-administration, mean daily ethanol intake varied markedly among them. "Like humans, rhesus macaques showed highly variable drinking behaviour. Some animals drank large volumes of ethanol, while others drank in moderation," Messaoudi said.
 

The animals' voluntary ethanol consumption segregated them into two groups: animals in the first group were those that consumed more alcohol, averaged a blood ethanol concentration (BEC) greater than the legal limit of 0.08 per cent and were therefore designated 'heavy drinkers'; animals in the second group consumed less alcohol, averaged a BEC of 0.02-0.04 per cent and were designated 'moderate drinkers.'
 

"Prior to consuming alcohol, all the animals showed comparable responses to vaccination. Following exposure to ethanol, however, the animals showed markedly different responses after receiving the booster vaccine," Messaoudi said. The researchers found that those animals that drank the
largest amounts of alcohol showed greatly diminished vaccine responses compared to the control group.

US-based Indian creates first artificial kidney

New Delhi: US-based Indian origin researcher Shuvo Roy has created the world’s first implantable artificial kidney. What’s sensational about Roy’s creation is that the organ, no larger than a coffee cup, will be able to mimic the kidney’s most vital functions like filtering toxins out of the bloodstream, regulate blood pressure and produce the all important vitamin D. The artificial kidney has been tested successfully on a small number of animals. Large-scale trials on animals and humans are expected over the next five years.

Once available, and if affordable, this creation by the Roy-led team at University of California will do away with the need for kidney dialysis. This will be a boon for all patients with chronic kidney disease (CKD). At present in India, of the 1.5 lakh new patients who suffer from endstage renal failure annually, only 3,500 get kidney transplants and 6,000-10,000 undergo dialysis. The rest perish due to an acute shortage of dialysis centres and nephrologists to man them. CKD is rising at a rapid pace in India and the majority of those who perish are either unable to find a suitable organ for transplantation or are unable to pay for the high dialysis costs.

According to Roy, the device has a filtration section to remove toxins from the blood, alongside a compartment with renal cells to conduct other functions of a kidney. He believes the artificial kidney could last for decades and require no pumps or batteries. Patients wouldn’t require anti-rejection drugs (as is required after transplants) either because there would be no exposed natural tissues for the immune system to attack. The University of California team is awaiting approval to conduct larger scale animal and human trials. Already, it has successfully tested the implant in a few rats and pigs. “The payoff to the patient community is tremendous,” said Roy.

“It could have a transformative impact on their lives...With the right financial support, I think we could reach clinical trials in five years. But it’s hard to say how long after that it becomes commercially available due to the uncertainties of the FDA and commercialization prospects.’’

THE ULTIMATE RELIEVER?
The artificial, implantable kidney developed by Dr Shuvo Roy is the size of a coffee cup and is ready for test on humans. If successful, it could replace the need for dialysis and transplants for lakhs of people suffering from chronic kidney diseases

The patient’s blood passes through two stages after entering the device
1- Filter Side: Silicon membranes filter the blood and remove toxins
2 - Cellular Side: A bed of kidney cells (grown with help of tissue engineering) regulates chemical balance of the blood

SHUVO ROY
Roy’s father is from India while his mother is a Bangladeshi. Born in Bangladesh, young Roy spent some time in India as well. Studied in Uganda, where his father was a doctor. Went to US for higher studies

KIDNEY DISEASE IN INDIA
Every year, 1.5 lakh new patients end up suffering from end-stage renal failure. Only 3,500 get transplants and 6,000 undergo dialysis. The rest die due to shortage of dialysis centres and nephrologists Patient undergoing dialysis  spends 10,000 a month, with the  process taking up to 72 hours ‘

Artificial kidney will be boon for India’
So what would this artificial kidney mean for India? ‘‘It will be a real boon,’’ said Dr S C Tiwari, director of nephrology and renal transplantion medicine at Fortis health care. He added: ‘‘The biggest problem with CKD patients in India is that majority of them are diagnosed in the final stages where they would either require constant dialysis or a transplant. They would require dialysis three times week. However, of the two lakh CKD patients requiring dialysis, only 10,000 get it, mainly because they can’t afford it. Maybe only 1,000 such patients get it for free or at a subsidized rate in government hospitals. The artificial kidney, when available and if affordable, will be a miracle.’’ Dr Madan Bahadur, nephrologist with Mumbai’s Jaslok Hospital added, ‘‘Work on creating tubular cells (that perform the biochemical work of the kidney) began a decade back. But bio-chemical engineering has so far not managed to replicate the kidney.’’ According to Dr Jitendra Kumar, head of nephrology at Asian Institute of Medical Sciences, the main reason why this artificial kidney will be a real breakthrough is because it will be able to mimic the vital functions of a kidney like regulate BP and produce vitamin D — things a dialysis can’t do.

Scientists unfold reasons for weak memory and brain aging

Diet lacking in omega-3 fatty acids -- nutrients found in fish -- may weaken memory and also accelerate brain ageing, according to a new study.

"People with lower blood levels of omega-3 fatty acids had lower brain volumes that were equivalent to about two years of structural brain ageing," said study author Zaldy S. Tan, geriatrics researcher at the University of California, Los Angeles. 

Some 1,575 people with an average age of 67-years and free of dementia, underwent MRI brain scans. They were also given tests to measure mental function, body mass and the omega-3 fatty acid levels in their red blood cells, the journal Neurology reports. 

Researchers found that people whose docosahexaenoic acid (DHA), an omega-3 fatty acids compound) levels were among the bottom 25 percent of the participants had lower brain volume compared to people who had higher DHA levels, according to a statement. 

Similarly, participants with levels of all omega-3 fatty acids in the bottom 25 percent also scored lower on tests of visual memory and executive function, such as problem solving and multi-tasking and abstract thinking.